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D o s e s of a t l e a s t 150 r a r e n e c e s s a r y t o p r o d u c e effect. 500 r produces erythema. E c z e m a , lichen planus, psoriasis, a n d e p i t h e l i o m a of t h e e y e l i d s m a y b e t r e a t e d . R a d i u m . — T h i s h a s b e e n l a r g e l y s u p p l a n t e d b y X - r a y u n i t s , b u t is still useful for t r e a t m e n t of o t h e r w i s e i n a c c e s s i b l e a r e a s , s u c h a s the mouth. T h o r i u m X . — T h i s is a s h o r t - l i v e d (half-life 3-64 d a y s ) r a d i o - a c t i v e element emitting alpha rays.

S o m e t i m e s n o d u l e s o r c y s t s d e v e l o p i n t h e opening. T h e r e m a y be a familial history, b u t isolated cases occur as w e l l . F e m a l e s a r e m o r e affected t h a n m a l e s . CONGENITAL EPIDERMAL CANALS PERINEAL RAPHE OF THE T h i s r a r e c o n d i t i o n p r e s e n t s a s a p e r s i s t e n t l y d r a i n i n g fistula o r c y s t . I n d u r a t i o n a r o u n d t h e fistula o r c y s t is u s u a l a n d i n f e c t i o n of i t is c o m m o n .

Cortisone with the P O R O K E R A T O S I S ( M I Β E L L I) (Hyperkeratosis Excentrica) A rare, chronic, progressive disorder, characterized atrophic patches, surrounded b y a raised keratotic edge. — A G E . — A p p e a r s in c h i l d h o o d , b u t s o m e t i m e s n o t n o t e d u n t i l p u b e r t y o r e a r l y a d u l t life. S E X . — M a l e s m o r e t h a n females, 2 : 1 . I N H E R I T A N C E . — T r a n s m i t t e d as a regular dominant. P a t h o l o g y . — K e r a t o t i c edge shows hyperkeratosis with a groove containing a h o r n y plug, t h e cornoid lamella, whose centre consists of p a r a k e r a t o t i c cells.

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