Download Advances in cancer research. Volume one hundred and twenty by Kenneth D Tew; Paul B Fisher PDF

By Kenneth D Tew; Paul B Fisher

Advances in melanoma Research offers beneficial info at the intriguing and fast-moving box of melanoma learn. right here, once more, remarkable and unique stories are offered on various topics.

  • Provides info on melanoma research
  • Outstanding and unique reviews
  • Suitable for researchers and students

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2. Targeting the proneural subgroup by PDGFR inhibition Platelet-derived growth factor isoform a and b form homo- or heterodimers upon ligand binding. Amplification of PDGFRA was identified in 11% of GBM patients (The Cancer Genome Atlas Research Network, 2008). , 2009). , 2013). , 2013). , 2012). 3 Association of pediatric H3F3A (G24 and K27) mutant high-grade gliomas to distinct brain regions Clinical Subgroup Target Inhibitor Other Targets Trials Reference Classical EGFR Gefitinib (lressa/ZD1839) – Yes Reardon et al.

Et al. (2010). Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 16(22), 5424–5435. CCR-10-1102. , Araujo Cruz, M. , et al. (2013). Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML. Blood, 122, 2877–2887. 1182/blood-2013-03491571. Chaumeil, M. , Larson, P. E. , Yoshihara, H. A. , Danforth, O.

Danforth, O. , Vigneron, D. , Nelson, S. , et al. (2013). Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nature Communications, 4, 2429. , Packer, R. , & Gallo, V. (2013). Modulation of the Wnt/betacatenin pathway in human oligodendroglioma cells by Sox17 regulates proliferation and differentiation. Cancer Letters, 335(2), 361–371. , McKay, R. , Burns, D. , Kernie, S. , et al. (2012). A restricted cell population propagates glioblastoma growth after chemotherapy. Nature, 488(7412), 522–526.

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