By B J A Furr
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Additional info for Aromatase inhibitors
Subsequently, these results have been confirmed in the clinic by the Arimidex, Tamoxifen Alone or in Combination (ATAC) trial . Patients with early breast cancer were treated with anastrozole, tamoxifen, or the combination. Treatment with anastrozole alone proved to be superior to tamoxifen, indicating for the first time that aromatase inhibitors were more effective in treating breast cancer patients than tamoxifen. However, treatment with the combination of anastrozole and tamoxifen was no better than with tamoxifen alone.
Arimidex Study Group. J Clin Oncol 18: 3758–3767 Coombes RC, Hall E, Gibson LJA (2004) Randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N Eng J Med 350: 1081–1092 Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ et al. (2003) A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. New Engl J Med 349: 1793–1802 Brodie AMH, Marsh DA, Wu JT, Brodie HJ (1979) Aromatase inhibitors and their use in controlling estrogen dependent processes.
N Eng J Med 350: 1081–1092 Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ et al. (2003) A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. New Engl J Med 349: 1793–1802 Brodie AMH, Marsh DA, Wu JT, Brodie HJ (1979) Aromatase inhibitors and their use in controlling estrogen dependent processes. J Steroid Biochem 11: 107–112 Brodie AMH, Wu JT, Marsh DA, Brodie HJ (1978) Aromatase inhibitors III. Studies on the antifertility effects of 4-acetoxy-4-androstene-3,17-dione.